Kala Azar (leishmaniasis)

Some three decades ago, a mystery disease spread throughout Sudan and what is now South Sudan, decimating communities, sewing fear, and killing scores. It turned out to be kala azar, also known as visceral leishmanaisis, a disease that is spread by the bite of a sandfly and that is, as this episode showed, fatal if not treated.MSF began caring for kala azar patients during that epidemic and has continued to do so through the present day, in both Sudan and South Sudan, and in other East African nations where the disease appears, as well as in South Asia. The needs are different in the different locations, because the strains of the disease found have their own particular characteristics. What unites them, however, is that the people trying to combat the disease are hamstrung by shortcomings in targeted research and development that has resulted in a lack of suitable diagnostics and treatment regimens.There are 400,000 new cases of kala azar diagnosed worldwide each year with approximately 40,000 deaths due to the parasitic disease. The eight most affected countries – Bangladesh, Brazil, India, Ethiopia, Kenya, Nepal, Sudan, and South Sudan – represent over 90 percent of new cases.MSF has successfully adapted its treatment protocols over the years in order to bring shorter, less toxic, and less painful options to patients, but as VII Photo’s John Stanmeyer saw on a recent trip to MSF projects in South Sudan, a great deal remains to be done in order to provide better, more specialized, more accessible treatment and testing, and to prevent further devastation.

Kala azar, or visceral leishmaniasis, is the second deadliest parasitic disease in the world – only malaria kills more people.

Also known as visceral leishmaniasis, kala azar is the most serious form of leishmaniasis and is endemic in 76 countries, with hundreds of millions at risk of infection. There are between 50,000 and 90,000 new cases a year, about 90 per cent of which occur in Brazil, Ethiopia, India, Kenya, Somalia, South Sudan and Sudan.

A neglected tropical disease, kala azar is caused by a parasite spread to humans through the bite of infected female sand flies. It attacks the immune system and is almost always fatal if not treated.

Diagnosis and treatment of the disease, especially of the variety found in eastern Africa, can be complex and painful.

76

The number of countries in which kala azar is endemic

200million

2million

The number of people at risk of infection

90%

9%

of cases are in India, Bangladesh, Nepal, Sudan and Brazil.

Putting kala azar in context

Along with chagas disease and sleeping sickness, kala azar is one of the most dangerous neglected tropical diseases. Kala azar is endemic in 76 countries with about 200 million people at risk of infection.

The parasite is spread to humans through the bite of infected female sand flies. It attacks the immune system, and is almost always fatal if not treated.

There are between 200,000 and 400,000 new cases a year, about 90 percent of which are in India, Bangladesh, Nepal, Sudan and Brazil.

About Kala Azar

What causes kala azar?

Kala azar is caused by bites from female phlebotomine sandflies – the vector (or transmitter) of the leishmania parasite.

The sandflies feed on animals and humans for blood, which they need for developing their eggs.

If blood containing leishmania parasites is drawn from an animal or human, the next person to receive a bite will then become infected and develop leishmaniasis.

Months after this initial infection, the disease can progress into a more severe form, called visceral leishmaniasis or, kala azar.

Kala azar presents after two to eight months, with more generalised symptoms, including prolonged fever and weakness.

Co-infection of kala azar and HIV is a major challenge, as the diseases influence each other in a vicious spiral as they attack and weaken the immune system.

Diagnosing kala azar

The most effective diagnostic tests for leishmaniasis are invasive and potentially dangerous, where tissue samples are required from the spleen, lymph nodes or bone marrow.

These tests require lab facilities and specialists not readily available in resource-poor, endemic areas.

The most common method of diagnosing kala azar is by dipstick testing. However, this method is highly problematic. In endemic areas, people can become infected with kala azar, but it may not develop into the disease.

Therefore, no treatment will be required.

Unfortunately, dipstick testing only establishes whether a patient is immune to kala azar – so if the parasite is present, it would appear that the patient has the disease. Because of this, dipstick testing can’t be used to see if the patient is cured, is re-infected or has relapsed.

Treating kala azar

Today, liposomal amphotericin B is becoming the primary treatment drug in Asia, either alone or as part of a combination therapy.

While safer and shorter than previously used medication, it requires intravenous administration, which remains an obstacle to its use in local clinics. An oral drug, miltefosine, is often added to optimise treatment regimens in patients.

In Africa, the best available treatment is still a combination of pentavalent antimonials and paromomycin, which is toxic and requires a number of painful injections. Research into other treatment combinations is underway.

MSF treated 9,900 patients for kala azar in 2018.

Neglected tropical diseases

No more neglected diseases, no more neglected patients

msf.org.za

Despite much progress in the fight against neglected tropical diseases, some of the most life-threatening diseases remain far from elimination or even control and continue to claim hundreds of thousands of lives every year. The World Health Organization’s ambitious targets include eliminating at least one of these diseases in 100 countries and reducing by 90 per cent the number of people requiring medical interventions for them by 2030.

From the frontlines

Treating HIV-kala azar co-infection

Kala azar-HIV co-infection is an emerging public health problem in Bihar, India. Kala azar, a neglected tropical disease spread through the bite of a sandfly, thrives in agricultural settings and is prevalent in Bihar. It's almost always fatal if left untreated. People living with HIV are far more likely to develop kala azar in places where it's endemic, creating an even more deadly combination. Since 2015, MSF has treated over 700 cases of HIV-kala azar co-infection.