Most maternal deaths occur just before, during or just after delivery. Timely access to qualified staff can be a question of life or death for women experiencing complications during childbirth. MSF works to remedy the 'three delays' women face in receiving care during childbirth: the delay in deciding to seek care; the delay in reaching a health facility; and the delay in receiving adequate treatment at the facility. Apart from emergency obstetric and newborn care we also provide pre- and postnatal care and contraceptive services.

Disease outbreaks can disproportionally affect pregnant women, particularly in later stages of pregnancy. Pregnant women are more susceptible to the effects of malaria infection, which can lead to maternal death, miscarriage or stillbirth. In some of our projects up to 50 percent of women in antenatal care may test positive for malaria. Hepatitis E has a significantly higher death rate amongst pregnant women, reaching 25 percent for women in the third trimester. In some cases cholera can lead to premature labour or obstetric complications. MSF's rapid response when an outbreak is identified ensure that the number of women at risk is quickly reduced and can significantly impact the number of women falling ill or at risk of death. 

In 2023, our teams provided medical care to over 62,200 victims of sexual violence; most were women and girls, but there is increasing awareness of sexual violence committed against men and boys. The care we offer covers preventive treatment against sexually transmitted infections including HIV, and vaccinations for tetanus and hepatitis B. Timely medical assistance is vital, as HIV prevention has to begin within 72 hours of the assault. Treatment of physical injuries, psychological support and the prevention and management of unwanted pregnancy are also included.

Obstructed and prolonged labour can result in a fistula: a hole between the vagina and bladder, the vagina and rectum, or both. The result is urinary and/or faecal incontinence. Women with fistulas live in shame and are often rejected by their families and communities. The operation to close a fistula requires specialised surgical skills. MSF has organised 'fistula camps' to provide surgery to women with fistula. Fistula can be easily prevented with access to skilled birth attendance and adequate management of obstructed labour, namely caesarean section.

Over 90 percent of children living with HIV are infected from their mothers during pregnancy, birth, or breastfeeding. Prevention of Mother-to-Child transmission (PMTCT) can reduce the likelihood of transmission to below two percent. We integrate PMTCT in mother and child care in places with medium- to high-HIV rates, where we need to support other efforts. It includes testing and providing antiretroviral (ARV) drugs to HIV-positive pregnant women, advice on breastfeeding, counselling and preventative ARVs to newborns. If, despite efforts, the baby is infected, then treatment is provided.

Cervical cancer rates are on the rise worldwide, particularly in the developing world, where the disease is the leading cause of cancer death for women in many countries. In several countries, we conduct cervical cancer screening and treat patients with early-stage disease. We put particular effort into high HIV prevalence contexts as HIV positive women are at much higher risk of cervical cancer, and have provided vaccinations against the human papillomavirus (HPV), one of the main causes of the disease. In 2019, we vaccinated 13,000 girls in Zimbabwe against HPV.